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There is an urban legend stating that daddy long-legs spiders have the most potent venom of any spider, but that their chelicerae (fangs) are either too small or too weak to puncture human skin

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After measuring the spider's fangs at approximately 0.25 mm (average human skin thickness varies from about 0.5mm to 4mm), the show's host was apparently bitten, although the bite produced little more than a mild short-lived burning sensation. This appears to confirm the suspicion that pholcids can penetrate human skin, but that their venom is practically harmless to humans. Additionally, recent research by Alan Van Dyke has shown that pholcid venom is actually relatively weak in its effects on insects as well.